化工社化工社 化学情報印刷レポート · 研究参考用
Bromine → 3-Bromo-6-methoxy-2-methylbenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 2-Methoxy-6-methylbenzoic acid | HCID 273170 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3-Bromo-6-methoxy-2-methylbenzoic acid | HCID 2752992 | 72.8% |
反応手順
A mixture of bromine (102 ml, 2.0 mol) and acetic acid (225 ml) is added to a mixture of 50A (304.0 g, 1.8 mol),), sodium acetate (164.0 g, 2.0 mol) and acetic acid (3.0 l) at a temperature of 10 to 15° C. The reaction mixture is stirred at room temperature for 16 hours. The solid material is collected by vacuum filtration, washed with water and dried yielding off-white crystals 321.0 g (72.6.%), mp 81-83° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05922905 |
| 出典データセット | uspto-grants-1999_07 |
| ORD ID | ord-bb81b3ba0d624d90b98bcaa84756b1a3 |
| 出典メモ | uspto-grants-1999_07 |