Methyl 2-cyanobenzoate → (2-(Aminomethyl)phenyl)methanol
反応式
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]#[N:11].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C(OCC)C>[NH2:11][CH2:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[CH2:3][OH:2]参加物
4
実験手順
A solution of methyl-2-cyanobenzoate (10 g, 62.11 mmol) in ethyl ether (300 mL) was added dropwise to a slurry of lithium aluminum hydride in ethyl ether (200 mL). After the addition was complete, more ether was added (200 mL) and the mixture heated at reflux for 2 h. The cooled reaction mixture was quenched by careful addition of succesive amounts of water (7.1 mL), 1N sodium hydroxide solution (7.1 mL) and water (21.3 mL). The reaction was filtered and evaporated to give 6.96 g (50.8 mmol) of 2-(aminomethyl)benzyl alcohol. This material was carried on without further purification.
後処理
- additionAfter the addition
- temperaturethe mixture heated
- temperatureat reflux for 2 h
- customThe cooled reaction mixture
- customwas quenched by careful addition of succesive amounts of water (7.1 mL), 1N sodium hydroxide solution (7.1 mL) and water (21.3 mL)
- filtrationThe reaction was filtered
- customevaporated
出典と根拠
- ORDレコード
- ord-9961a782de6f450db167dc0f29472df2
- 出典データセット
- uspto-grants-1999_07
- 特許番号
- US05925635
反応ノート
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