Toluene → 3-Methyl-N-phenylbutanimidic acid

反応式

C([C:4]1[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=1[NH2:6])(C)C.C(O[C:15](=[O:17])[CH3:16])(=O)C.[C:18]1(C)[CH:23]=CC=C[CH:19]=1>>[CH:18]([CH2:16][C:15]([NH:6][C:5]1[CH:4]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:17])([CH3:23])[CH3:19]

参加物

反応物 3

HCID 1140Toluene

HCID 7918Acetic Anhydride

HCID 125612-Isopropylaniline

生成物 1

HCID 2229413-Methyl-N-phenylbutanimidic acid

実験手順

A mixture containing 300 ml of toluene and 31 ml of 2-isopropylaniline is cooled in ice, and 22 ml of acetic anhydride are added slowly. After 40 minutes with stirring at RT, the reaction medium is evaporated and the residue is then taken up with petroleum ether. The precipitate formed is drained. 35.9 g of the expected product are obtained after crystallization in petroleum ether, m.p.=81° C.