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HRID 582776作成日：2026年10月26日
Sulfuric Acid → 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[N-methyl-N-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid hydrogen sulphate
https://huagongshe.com/reaction/582776
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | SR142948A | HCID 5311451 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[N-methyl-N-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid hydrogen sulphate | HCID 70246179 | 94.5% |
反応手順
0.5 g of the compound obtained in EXAMPLE 1' is added to a solution of 0.08 g of H2SO4 in 5 ml of MeOH, this solution is poured into 150 ml of ether cooled to 5° C., and the precipitate formed is drained. 0.54 g of the expected product is obtained. After recrystallization in water, m.p.=212° C. (dec.). After recrystallization in 2-isopropanol, m.p.=263° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05925661 |
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| 出典データセット | uspto-grants-1999_07 |
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| ORD ID | ord-6743dd7029a74400a67f9515d89c49fc |
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| 出典メモ | uspto-grants-1999_07 |
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