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HRID 582783作成日：2026年10月27日
Diethyl Ether → 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[n-methyl-n-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid sodium salt
https://huagongshe.com/reaction/582783
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | SR142948A | HCID 5311451 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 触媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[n-methyl-n-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid sodium salt | HCID 70244978 | 70.6% |
反応手順
0.206 g of the compound obtained in EXAMPLE 1' and 0.026 g of sodium methylate are dissolved in 1 ml of MeOH and a few drops of DCM, and this solution is then poured into 50 ml of ether cooled to 5° C. The gelatinous precipitate formed is drained and dried over P2O5 and under vacuum. 0.15 g of the expected product is obtained, m.p.=191° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05925661 |
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| 出典データセット | uspto-grants-1999_07 |
|---|
| ORD ID | ord-41a11cde5d9041268bccfdadb4d9cc1e |
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| 出典メモ | uspto-grants-1999_07 |
|---|
