Isethionic Acid → 2-Hydroxyethane-1-sulfonic acid--6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine (1/1)

HRID 582804ノート

反応式

HRID 582804 の反応式
[S:1]([CH2:5][CH2:6][OH:7])([OH:4])(=[O:3])=[O:2].S(O)(=O)(=O)C.[NH2:13][C:14]1[N:15]=[N:16][C:17]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[C:22]=2[Cl:28])=[C:18]([NH2:20])[N:19]=1>>[S:1]([CH2:5][CH2:6][OH:7])([OH:4])(=[O:3])=[O:2].[NH2:13][C:14]1[N:15]=[N:16][C:17]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[C:22]=2[Cl:28])=[C:18]([NH2:20])[N:19]=1

参加物

3

反応物 2

HCID 7866Isethionic AcidHCID 9841402187106-86-1

生成物 1

HCID 450396462-Hydroxyethane-1-sulfonic acid--6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine (1/1)

実験手順

50 mmol of Amberlite (trade mark) IR-45 (OH) was mixed with 15 mmol (10 ml) aqueous isethionic acid and the resulting material was packed into a column. The column was then washed with methanol. 0.7 g (2 mmol) of a methanolic solution of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine mesylate was eluted through the column. The elutant was evaporated in vacuo and the residue was recrystallised from industrial methylated spirit and gave 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate:

後処理

  1. washThe column was then washed with methanol
  2. customThe elutant was evaporated in vacuo
  3. customthe residue was recrystallised from industrial methylated spirit

出典と根拠

ORDレコード
ord-bd9844620d61412e8d50cc58eb4ce9f2
出典データセット
uspto-grants-1999_07
特許番号
US05925755

反応ノート

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