Ethyl 3-(2-bromoethoxy)-2-methylbenzoate → Ethyl 3-(2-methylsulfonylthioethoxy)-2-methylbenzoate

HRID 582822ノート

反応式

HRID 582822 の反応式
Br[CH2:2][CH2:3][O:4][C:5]1[C:6]([CH3:16])=[C:7]([CH:13]=[CH:14][CH:15]=1)[C:8]([O:10][CH2:11][CH3:12])=[O:9].[CH3:17][S:18]([O-:21])(=[S:20])=[O:19].[K+]>C(O)C>[CH3:17][S:18]([S:20][CH2:2][CH2:3][O:4][C:5]1[C:6]([CH3:16])=[C:7]([CH:13]=[CH:14][CH:15]=1)[C:8]([O:10][CH2:11][CH3:12])=[O:9])(=[O:21])=[O:19]

参加物

4

反応物 2

HCID 15376195Ethyl 3-(2-bromoethoxy)-2-methylbenzoateHCID 23696406Potassium thiomethanesulfonate

生成物 1

HCID 15376196Ethyl 3-(2-methylsulfonylthioethoxy)-2-methylbenzoate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2 g (7 mmol) of ethyl 3-(2-bromoethoxy)-2-methylbenzoate and 1.1 g (7.3 mmol) of potassium thiomethanesulfonate are dissolved in 10 ml absolute ethanol. The reaction mixture is refluxed for 20 hours. The solvent is then distilled off and the residue taken up in methylene chloride and washed with water. The organic phase is dried over sodium sulfate and the solvent is removed. The product of value is purified by column chromatography.

後処理

  1. temperatureThe reaction mixture is refluxed for 20 hours
  2. distillationThe solvent is then distilled off
  3. washwashed with water
  4. dry with materialThe organic phase is dried over sodium sulfate
  5. customthe solvent is removed
  6. customThe product of value is purified by column chromatography

出典と根拠

ORDレコード
ord-971a12ba684246ea9e0f633a678e70d6
出典データセット
uspto-grants-1999_07
特許番号
US05925767

反応ノート

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