HCID 56999066、化合物 → HCID 12916445、化合物

HRID 582900ノート

反応式

HRID 582900 の反応式
[O:1]1[C@H:7]([CH2:8][CH2:9]CCCCCCCCCCCCC)[C@H:2]1[C:3]([O:5][CH3:6])=[O:4]>CO>[O:1]1[C@H:7]([CH2:8][CH3:9])[C@H:2]1[C:3]([O:5][CH3:6])=[O:4]

参加物

3

反応物 1

HCID 56999066HCID 56999066、化合物

生成物 1

HCID 12916445HCID 12916445、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

In 500 ml of methanol were dissolved 62.4 g (0.2 mol) of the methyl (2S,3R)-2,3-epoxyoctadecanoate (V-1) obtained in (3) above and 7.4 g (0.2 mol) of sodium hydroxide, and the solution was stirred for 3 hours. After confirming disappearance of the compound (V-1) by TLC, methanol was evaporated. The resulting concentrate was adjusted to pH 5 to 6 with 500 ml of diluted hydrochloric acid and extracted with 500 ml of ethyl acetate. After drying, ethyl acetate was evaporated, and the resulting crude crystals were recrystallized from a 5-fold volume of heptane to afford 42.6 g (0.15 mol; yield: 75%) of the title compound (V-2) (melting point: 186° C.).

出典と根拠

ORDレコード
ord-8e659c68da8245fca8c3d1c9689cd8bb
出典データセット
uspto-grants-1999_07
特許番号
US05925792

反応ノート

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