3-(2-(2-(2-(Trifluoromethoxy)tetrafluoroethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)propyl chloride → 2-Octyloxy-7-(3-(2-(2-(2-(trifluoromethoxy)tetrafluoroethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)propoxy)fluorene
反応式
[CH2:1]([O:9][C:10]1[CH:22]=[CH:21][C:20]2[C:19]3[C:14](=[CH:15][C:16]([OH:23])=[CH:17][CH:18]=3)[CH2:13][C:12]=2[CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[F:24][C:25]([F:51])([F:50])[O:26][C:27]([F:49])([F:48])[C:28]([F:47])([F:46])[O:29][C:30]([F:45])([F:44])[C:31]([F:43])([F:42])[O:32][C:33]([F:41])([F:40])[CH2:34][O:35][CH2:36][CH2:37][CH2:38]Cl.FC(F)(F)OC(F)(F)C(F)(F)OC(F)(F)C(F)(F)OC(F)(F)COCCCBr>>[CH2:1]([O:9][C:10]1[CH:22]=[CH:21][C:20]2[C:19]3[C:14](=[CH:15][C:16]([O:23][CH2:38][CH2:37][CH2:36][O:35][CH2:34][C:33]([O:32][C:31]([F:42])([F:43])[C:30]([F:44])([F:45])[O:29][C:28]([F:46])([F:47])[C:27]([F:48])([F:49])[O:26][C:25]([F:51])([F:50])[F:24])([F:41])[F:40])=[CH:17][CH:18]=3)[CH2:13][C:12]=2[CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]参加物
4
反応物 3
生成物 1
実験手順
The title compound was prepared essentially as in Example 1 by combining 2-octyloxy-7-hydroxyfluorene (1.0 g, 3.2 mmol) with a mixture of 3-(2-(2-(2-(trifluoromethoxy)tetrafluoroethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)propyl chloride and 3-(2-(2-(2-(trifluoromethoxy)tetrafluoroethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)propyl bromide (total 1.62 g, 3.3 mmol, 80:20 mole ratio). The reaction mixture was quenched by addition of water, and the resulting crude product was recrystallized from ethanol and further purified by Kugelrohr distillation (188° C. at 0.01 torr) to provide a yield of 0.84 g.
後処理
- customThe reaction mixture was quenched by addition of water
- customthe resulting crude product was recrystallized from ethanol
- distillationfurther purified by Kugelrohr distillation (188° C. at 0.01 torr)
- customto provide a yield of 0.84 g
出典と根拠
- ORDレコード
- ord-40f70ba16887488aaec23fbd3dbdc9e5
- 出典データセット
- uspto-grants-1999_07
- 特許番号
- US05928562
反応ノート
読み込み中…