5-Octyloxy-2-(3-fluorophenyl)pyrimidine → 5-Octyloxy-2-[4-(3-(2-(2-(trifluoromethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)propoxy)-3-fluorophenyl]pyrimidine
反応式
[CH2:1]([O:9][C:10]1[CH:11]=[N:12][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=2)=[N:14][CH:15]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].C(OC1C=NC(C2C=CC([O:42][CH2:43][CH2:44][CH2:45][O:46][CH2:47][C:48]([O:51][C:52]([F:62])([F:61])[C:53]([F:60])([F:59])[O:54][C:55]([F:58])([F:57])[F:56])([F:50])[F:49])=CC=2)=NC=1)CCCCC>>[CH2:1]([O:9][C:10]1[CH:15]=[N:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([O:42][CH2:43][CH2:44][CH2:45][O:46][CH2:47][C:48]([O:51][C:52]([F:61])([F:62])[C:53]([F:59])([F:60])[O:54][C:55]([F:57])([F:58])[F:56])([F:50])[F:49])=[C:18]([F:22])[CH:17]=2)=[N:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]参加物
3
反応物 2
生成物 1
実験手順
The title compound was prepared essentially as in Example 1 by combining 5-octyloxy-2-(3-fluorophenyl)pyrimidine (2.0 g, 6.3 mmol) with 3-(2-(2-(trifluoromethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)propoxy chloride (2.5 g, 7.0 mmol, Example 17). The reaction mixture was quenched with water, and the resulting crude product was further purified by recrystallization from ethanol, followed by Kugelrohr distillation (210-18° C. at 0.15 torr), to provide a yield of 3.2 g.