5-Hexyloxy-2-[4-(5-(2-(2-(pentafluoroethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)pentyloxy)phenyl]pyrimidine → HCID 21225397、化合物

HRID 583002ノート

反応式

HRID 583002 の反応式
[CH2:1]([O:9][C:10]1[CH:11]=[N:12][C:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[C:18]([F:23])[CH:17]=2)=[N:14][CH:15]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].C(OC1C=NC(C2C=CC(O[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][O:49][CH2:50][C:51]([O:54][C:55]([F:68])([F:67])[C:56]([F:66])([F:65])[O:57][C:58]([F:64])([F:63])[C:59]([F:62])([F:61])[F:60])([F:53])[F:52])=CC=2)=NC=1)CCCCC>>[CH2:1]([O:9][C:10]1[CH:15]=[N:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][O:49][CH2:50][C:51]([O:54][C:55]([F:67])([F:68])[C:56]([F:65])([F:66])[O:57][C:58]([F:63])([F:64])[C:59]([F:60])([F:61])[F:62])([F:53])[F:52])=[C:18]([F:23])[CH:17]=2)=[N:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

参加物

3

反応物 2

HCID 212253415-Hexyloxy-2-[4-(5-(2-(2-(pentafluoroethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)pentyloxy)phenyl]pyrimidineHCID 135590745HCID 135590745、化合物

生成物 1

HCID 21225397HCID 21225397、化合物

実験手順

The title compound was prepared essentially as in Example 1 by combining 5-octyloxy-2-[4-hydroxy-3-fluorophenyl)pyrimidine (1.5 g, 4.7 mmol) with 5-(2-(2-(pentafluoroethoxy)tetrafluoroethoxy)-2,2-difluoroethoxy)pentyl chloride (2.45 g, 5.1 mmol, Example 22). The reaction mixture was quenched with water, and the resulting crude product was further purified by recrystallization from ethanol, followed by Kugelrohr distillation (210° C. at 0.5 torr), to provide a yield of 2.6 g.

後処理

  1. customThe reaction mixture was quenched with water
  2. customthe resulting crude product was further purified by recrystallization from ethanol
  3. distillationfollowed by Kugelrohr distillation (210° C. at 0.5 torr)
  4. customto provide a yield of 2.6 g

出典と根拠

ORDレコード
ord-cfa9e2faae37424b9c4631ac2b135637
出典データセット
uspto-grants-1999_07
特許番号
US05928562

反応ノート

読み込み中…