1-(7-Methoxynaphthalen-1-yl)piperazine → 1-[2-(5-Methoxy-1H-inden-3-yl)ethyl]-4-(7-methoxynaphth-1-yl)piperazine
反応式
CC1C=CC(S(O[CH2:12][CH2:13][C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([O:23][CH3:24])[CH:21]=3)[CH2:16][CH:15]=2)(=O)=O)=CC=1.[CH3:25][O:26][C:27]1[CH:36]=[C:35]2[C:30]([CH:31]=[CH:32][CH:33]=[C:34]2[N:37]2[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]2)=[CH:29][CH:28]=1>ClCCl>[CH3:24][O:23][C:20]1[CH:21]=[C:22]2[C:17](=[CH:18][CH:19]=1)[CH2:16][CH:15]=[C:14]2[CH2:13][CH2:12][N:40]1[CH2:39][CH2:38][N:37]([C:34]2[C:35]3[C:30](=[CH:29][CH:28]=[C:27]([O:26][CH3:25])[CH:36]=3)[CH:31]=[CH:32][CH:33]=2)[CH2:42][CH2:41]1参加物
4
反応条件
- 温度
- 130 °C
実験手順
2.07 g (0.006 mol) of 2-(5-methoxy-1H-inden-3-yl)ethyl 4-methylbenzenesulphonate and 2.90 g (0.012 mol) of 1-(7-methoxynaphth-1-yl)piperazine are mixed and the mixture is stirred, is placed under an argon atmosphere and is heated in an oil bath at 130° C. for 2 h. The mixture is taken up in dichloromethane, the solution is washed with water, with dilute sodium hydroxide and then again with water, is dried over magnesium sulphate and is filtered and the filtrate is evaporated under reduced pressure. 4.08 g of an oil are obtained, which oil is purified by chromatography on a column of silica gel, elution being carried out with a 92/8 dichloromethane/acetone mixture.