2-Nitro-4-(trifluoromethyl)phenol → 2-Bromo-6-nitro-4-(trifluoromethyl)phenol
反応式
[Br:1]Br.[N+:3]([C:6]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[CH:8][C:7]=1[OH:16])([O-:5])=[O:4]>CC(O)=O>[Br:1][C:8]1[CH:9]=[C:10]([C:12]([F:13])([F:14])[F:15])[CH:11]=[C:6]([N+:3]([O-:5])=[O:4])[C:7]=1[OH:16]参加物
4
反応条件
- 温度
- 40 °C
実験手順
4.0 g of bromine in 7.3 mL of AcOH was added dropwise to a solution of 4.0 g of 2-nitro-4-trifluoromethyl-phenol and 300 mg FeCl3 in 23.1 mL of AcOH at 0° C. Reaction was then heated at 40° C. for 1.5 h. and then allowed to stir for 65 h at rt. Solvent was then removed, placed solid back into EtOAc, filtered through celite and concentrated in vacuo. 5 g of title compound was collected.
後処理
- customReaction
- customSolvent was then removed
- filtrationfiltered through celite and
- concentrationconcentrated in vacuo
- custom5 g of title compound was collected
出典と根拠
- ORDレコード
- ord-869dc7ab0e084aa0accb35075140560d
- 出典データセット
- uspto-grants-1999_07
- 特許番号
- US05929094
反応ノート
読み込み中…