Lithium Chloride → N2-(tert-butoxycarbonyl)-N2-methyl-N-[3-(triphenylphosphonio)propyl]glycinamide chloride

HRID 58334ノート

反応式

HRID 58334 の反応式
[C:1]([O:5][C:6]([N:8]([CH3:35])[CH2:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][P+:16]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[Br-].[Cl-:37].[Li+]>C(Cl)Cl.[Cl-].C([N+](CCCC)(CCCC)CCCC)CCC>[C:1]([O:5][C:6]([N:8]([CH3:35])[CH2:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][P+:16]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)=[O:11])=[O:7])([CH3:3])([CH3:4])[CH3:2].[Cl-:37]

参加物

5

反応物 2

HCID 433294Lithium ChlorideHCID 131737003HCID 131737003、化合物

生成物 1

HCID 131737005N2-(tert-butoxycarbonyl)-N2-methyl-N-[3-(triphenylphosphonio)propyl]glycinamide chloride

試薬・触媒・溶媒 2

HCID 70681Tetrabutylammonium Chloride触媒HCID 6344Dichloromethane溶媒

実験手順

A solution of N2-(tert-butoxycarbonyl)-N2-methyl-N-[3-(triphenylphosphonio)propyl]glycinamide bromide (53.7 g, 93.9 mmole) in methylene chloride (450 mL) was stirred with 20 weight percent aqueous lithium chloride containing 2 weight percent tetrabutylammonium chloride (4×150 mL/g). The organic layer was concentrated to dryness give the title compound in quantitative yield.

後処理

  1. concentrationThe organic layer was concentrated to dryness

出典と根拠

ORDレコード
ord-b3621d7d8476470a9c265f26cb6cbc17
出典データセット
uspto-grants-2016_09
特許番号
US09434753B2

反応ノート

読み込み中…