2-[(4-Methoxy-benzenesulfonyl)-methyl-amino]-3-methyl-5-[2-(methyl-octyl-carbamoyl)-vinyl]-benzoic acid methyl ester → 2-[(4-Methoxy-benzenesulfonyl)-methyl-amino]-3-methyl-5-[2-(methyl-octyl-carbamoyl)-vinyl]-benzoic acid

HRID 583356

反応式

HRID 583356 の反応式
C[O:2][C:3](=[O:38])[C:4]1[CH:9]=[C:8]([CH:10]=[CH:11][C:12](=[O:23])[N:13]([CH3:22])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH:7]=[C:6]([CH3:24])[C:5]=1[N:25]([S:27]([C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=1)(=[O:29])=[O:28])[CH3:26]>CCCCCC.CCOC(C)=O>[CH3:37][O:36][C:33]1[CH:34]=[CH:35][C:30]([S:27]([N:25]([CH3:26])[C:5]2[C:6]([CH3:24])=[CH:7][C:8]([CH:10]=[CH:11][C:12](=[O:23])[N:13]([CH3:22])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[CH:9][C:4]=2[C:3]([OH:38])=[O:2])(=[O:29])=[O:28])=[CH:31][CH:32]=1

参加物

3

反応物 1

HCID 700537552-[(4-Methoxy-benzenesulfonyl)-methyl-amino]-3-methyl-5-[2-(methyl-octyl-carbamoyl)-vinyl]-benzoic acid methyl ester

生成物 1

HCID 700520922-[(4-Methoxy-benzenesulfonyl)-methyl-amino]-3-methyl-5-[2-(methyl-octyl-carbamoyl)-vinyl]-benzoic acid収率 93%

試薬・触媒・溶媒 1

HCID 21226206Ethyl acetate hexane溶媒

実験手順

In the same manner as described in Example 18, 188 mg (0.35 mmol) of the product of Example 205 provided 170 mg (93%) of the desired carboxylic acid as a white solid after trituration with Hexane/EtOAc (2:1). Electrospray Mass Spec 575(M+HCOOH--H).

出典と根拠

ORDレコード
ord-89bbcc4564d54ab395fa5b098c76aa96
出典データセット
uspto-grants-1999_07
特許番号
US05929097

関連ノート

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