Benzyl Bromide → HCID 54357009、化合物

HRID 583376ノート

反応式

HRID 583376 の反応式
[NH2:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]([CH3:12])[C:3]=1[C:4]([OH:6])=[O:5].[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+].[I-]>CC(C)=O>[CH2:13]([O:5][C:4](=[O:6])[C:3]1[C:7]([CH3:12])=[CH:8][CH:9]=[C:10]([CH3:11])[C:2]=1[NH2:1])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

6

反応物 4

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 30165Iodide IonHCID 2757742-amino-3,6-dimethylbenzoic acid

生成物 1

HCID 54357009HCID 54357009、化合物収率 48%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 940 mg (5.73 mmol) of 2-amino-3,6-dimethylbenzoic acid, 0.750 ml (6.3 mmol) of benzyl bromide, 1.04 g (7.5mmole) of potassium carbonate and 40 mg (0.27mmole) of soium iodide in 20 ml of acetone was heated to reflux for 20 hr. The resulting mixture was then concentrated in vacuo and the residue was chronatoghed with EtOAc/Hexane (1:50) as eluant to provide 697 mg (48%) of the desired product as a yellow oil. Electrospray Mass Spec 256 (M+H).

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 20 hr
  3. concentrationThe resulting mixture was then concentrated in vacuo

出典と根拠

ORDレコード
ord-1008da67a5e54197b2b7481a8f9f2134
出典データセット
uspto-grants-1999_07
特許番号
US05929097

反応ノート

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