1-Dodecyne → 5-Dodec-1-ynyl-2-[(4-methoxy-benzenesulfonyl)-methyl-amino]-3-methyl-benzoic acid methyl ester

反応式

[CH:1]#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[CH3:13][O:14][C:15](=[O:37])[C:16]1[CH:21]=[C:20](Br)[CH:19]=[C:18]([CH3:23])[C:17]=1[N:24]([S:26]([C:29]1[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=1)(=[O:28])=[O:27])[CH3:25]>>[CH3:13][O:14][C:15](=[O:37])[C:16]1[CH:21]=[C:20]([C:1]#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH:19]=[C:18]([CH3:23])[C:17]=1[N:24]([S:26]([C:29]1[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=1)(=[O:28])=[O:27])[CH3:25]

参加物

反応物 2

HCID 698211-Dodecyne

HCID 699040625-Bromo-2-[(4-methoxy-benzenesulfonyl)-methyl-amino]-3-methyl-benzoic acid methyl ester

生成物 1

HCID 700558165-Dodec-1-ynyl-2-[(4-methoxy-benzenesulfonyl)-methyl-amino]-3-methyl-benzoic acid methyl ester収率 73%

実験手順

Following the procedure of Example 351, using 1-dodecyne instead of ethynyl biphenyl, 1.0 g (2.336 mmol) of the product of Example 202 gives 0.874 g (73%) of the alkyne as a brown oil. Electrospray Mass Spec: 514.4 (M+H)+.

出典と根拠

ORDレコード: ord-4403d977e32043289df75bdc2dd5bd5b
出典データセット: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05929097

反応ノート

読み込み中…