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2-Mercaptobenzoic Acid → 2-[2-(4-Sulfamoylphenylcarbamoyl)phenyldisulfanyl]benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Mercaptobenzoic Acid | HCID 5443 | — |
| 反応物 | 4-(3-Oxo-1,2-benzothiazol-2-yl)benzenesulfonamide | HCID 462938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-[2-(4-Sulfamoylphenylcarbamoyl)phenyldisulfanyl]benzoic acid | HCID 10766395 | 95.5% |
反応手順
This compound was prepared according to the method of Example 132 using a suspension of 0.46 g (1.5 mmol) of 4-(3-oxo-3H-benzo[d]isothiazol-2-yl)benzene sulfonamide in a mixture of 15 mL of methanol and 15 mL of tetrahydrofuran, and 0.23 g (1.5 mmol) of thiosalicylic acid. The product was washed with ether and dried in vacuo to give 0.66 g of the title compound, mp 276-278° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05929114 |
| 出典データセット | uspto-grants-1999_07 |
| ORD ID | ord-06d07131611a49eea4000e4123af0765 |
| 出典メモ | uspto-grants-1999_07 |