Hydrochloric Acid → (S)-2-[(S)-3-(4-Allyloxy-phenyl)-2-amino-propionylamino]-4-methyl-pentanoic acid methyl ester hydrogen chloride salt

HRID 58362ノート

反応式

HRID 58362 の反応式
[CH3:1][O:2][C:3](=[O:32])[C@@H:4]([NH:9][C:10](=[O:31])[C@@H:11]([NH:23]C(OC(C)(C)C)=O)[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH:21]=[CH2:22])=[CH:15][CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[ClH:33]>O1CCOCC1>[ClH:33].[CH3:1][O:2][C:3](=[O:32])[C@@H:4]([NH:9][C:10](=[O:31])[C@@H:11]([NH2:23])[CH2:12][C:13]1[CH:14]=[CH:15][C:16]([O:19][CH2:20][CH:21]=[CH2:22])=[CH:17][CH:18]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86650238(S)-2-[(S)-3-(4-Allyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoic acid methyl ester

生成物 1

HCID 66847093(S)-2-[(S)-3-(4-Allyloxy-phenyl)-2-amino-propionylamino]-4-methyl-pentanoic acid methyl ester hydrogen chloride salt

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Methyl ester 1 (4.00 g, 8.92 mmol) was dissolved in 4M HCl in 1,4-dioxane (20 mL). The resultant solution was stirred at rt for 18 h before being concentrated in vacuo to yield a white solid, 3.43 g, 100%.

後処理

  1. concentrationbefore being concentrated in vacuo
  2. customto yield a white solid, 3.43 g, 100%

出典と根拠

ORDレコード
ord-80e86ca51fe94179817a5886ec0c88da
出典データセット
uspto-grants-2016_09
特許番号
US09434762B2

反応ノート

読み込み中…