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Dimethylformamide → N-[(Phenylmethoxy)carbonyl]-L-tyrosine methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | N-benzyloxycarbonyl-l-tyrosine | HCID 712438 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | N-[(Phenylmethoxy)carbonyl]-L-tyrosine methyl ester | HCID 7010613 | — |
反応手順
A suspension of Cs2CO3 (0.65 g, 2.0 mmol), N-Cbz-L-tyrosine (1.3 g, 4.0 mmol; Bachem) and DMF (40 mL) at ambient temperature was treated with methyl iodide (0.5 mL, 4.0 mmol). After 2.0 h the reaction mixture was diluted with EtOAc and then washed with H2O and brine, dried (MgSO4) and concentrated. Flash chromatography (silica, 25% EtOAc/hexanes) gave 6-4 as a white solid. Rf 0.53 (silica, 50% EtOAc/hexanes).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05929120 |
| 出典データセット | uspto-grants-1999_07 |
| ORD ID | ord-eb812512c8894e4290944b83353259a2 |
| 出典メモ | uspto-grants-1999_07 |