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Triethylamine → 3,4,5-Trimethoxyphenyl 6-methoxy-3-pyridinesulfonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3,4,5-Trimethoxyphenol | HCID 69505 | — |
| 反応物 | 6-Methoxypyridine-3-sulfonyl chloride | HCID 22344709 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 3,4,5-Trimethoxyphenyl 6-methoxy-3-pyridinesulfonate | HCID 10286875 | 83.3% |
反応手順
A solution of 2-methoxypyridine-5-sulfonylchloride (314 mg, 1.51 mmol) in dichloromethane (15 mL) was treated with triethylamine (0.63 mL) and 3,4,5-trimethoxyphenol (279 mg, 1.51 mmol), stirred for 18 hours at room temperature, diluted with ethyl acetate, washed three times with 1M Na2CO3, dried (MgSO4), filtered, and concentrated to provide 447 mg of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06924304B2 |
| 出典データセット | uspto-grants-2005_08 |
| ORD ID | ord-e5cf63a01e114696b9636a9a1471802b |
| 出典メモ | uspto-grants-2005_08 |