Hydrochloric Acid → cis-4-(4-Chloro-3-trifluoromethyl-phenyl)-2,6-dimethyl-1-propyl-piperazine

HRID 584075ノート

反応式

HRID 584075 の反応式
Br[C:2]1[CH:3]=[CH:4][C:5]([Cl:12])=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH3:13][C@H:14]1[CH2:19][NH:18][CH2:17][C@@H:16]([CH3:20])[N:15]1[CH2:21][CH2:22][CH3:23].Cl>>[Cl:12][C:5]1[CH:4]=[CH:3][C:2]([N:18]2[CH2:17][C@@H:16]([CH3:20])[N:15]([CH2:21][CH2:22][CH3:23])[C@@H:14]([CH3:13])[CH2:19]2)=[CH:7][C:6]=1[C:8]([F:11])([F:10])[F:9]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 679594-Bromo-2-chloro-alpha,alpha,alpha-trifluorotolueneHCID 28363798(2R,6S)-2,6-Dimethyl-1-propylpiperazine

生成物 1

HCID 68443155cis-4-(4-Chloro-3-trifluoromethyl-phenyl)-2,6-dimethyl-1-propyl-piperazine

実験手順

Beginning with 5-bromo-2-chlorobenzotrifluoride and cis-2,6-dimethyl-1-propyl-piperazine, the title compound was recovered by the procedure described in Preparation 9: m.p. 256° C. (HCl), MS m/z (rel. intensity, 70 eV)) 335 (M+, 5), 305 (55), 112 (bp), 70 (67), 56 (82).

後処理

  1. customthe title compound was recovered by the procedure
  2. customdescribed in Preparation 9

出典と根拠

ORDレコード
ord-f7c3e7476ee44cde8da15c899200e694
出典データセット
uspto-grants-2005_08
特許番号
US06924374B2

反応ノート

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