Piperazine → 1-(4-Chloro-3-(trifluoromethyl)phenyl)piperazine

反応式

Br[C:2]1[CH:3]=[CH:4][C:5]([Cl:12])=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[Cl:12][C:5]1[CH:4]=[CH:3][C:2]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:7][C:6]=1[C:8]([F:11])([F:10])[F:9]

参加物

反応物 2

HCID 4837Piperazine

HCID 679594-Bromo-2-chloro-alpha,alpha,alpha-trifluorotoluene

生成物 1

HCID 27781371-(4-Chloro-3-(trifluoromethyl)phenyl)piperazine収率 78.2%

実験手順

Beginning with 5-bromo-2-chlorobenzotrifluoride (602 mg) and piperazine (1 g), 480 mg of the title compound was recovered by the procedure described in Example 1.

出典と根拠

ORDレコード: ord-aaf69014045a4df48cfb5c6eab8843aa
出典データセット: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06924374B2

反応ノート

読み込み中…