1-Chloro-2-iodo-4-(trifluoromethyl)benzene → 4-(2-Chloro-5-trifluoromethyl-phenyl)-1-propyl-piperidin-4-ol

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1I.[CH2:13]([N:16]1[CH2:21][CH2:20][C:19](=[O:22])[CH2:18][CH2:17]1)[CH2:14][CH3:15]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[C:19]1([OH:22])[CH2:20][CH2:21][N:16]([CH2:13][CH2:14][CH3:15])[CH2:17][CH2:18]1

参加物

反応物 2

HCID 695961-Chloro-2-iodo-4-(trifluoromethyl)benzene

HCID 900061-Propyl-4-piperidone

生成物 1

HCID 223451614-(2-Chloro-5-trifluoromethyl-phenyl)-1-propyl-piperidin-4-ol

実験手順

Beginning with 4-chloro-3-iodobenzotrifluoride and 1-propyl-4-piperidone, the titled compound was recovered by the procedure described in Preparation 4, MS m/z (rel. intensity, 70 eV)) 321 (M+, 8), 294 (38), 292, (bp), 274 (52), 56 (35).

後処理

customthe titled compound was recovered by the procedure
customdescribed in Preparation 4, MS m/z (rel. intensity, 70 eV)) 321 (M+, 8), 294 (38), 292, (bp), 274 (52), 56 (35)

出典と根拠

ORDレコード: ord-ecee86ef583740cc81a6ced5b0fbbf50
出典データセット: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06924374B2

反応ノート

読み込み中…

参加物