反応式
[N:1]1[CH:6]=[CH:5][N:4]=[C:3]2[C:7]([O:9][C:10](=[O:11])[C:2]=12)=[O:8].[CH2:12]([NH2:16])[CH2:13][CH2:14][NH2:15]>C(O)C>[NH2:15][CH2:14][CH2:13][CH2:12][NH:16][C:7]([C:3]1[C:2]([C:10]([OH:9])=[O:11])=[N:1][CH:6]=[CH:5][N:4]=1)=[O:8]参加物
4
実験手順
To a solution of 2,3-pyrazinedicarboxylic anhydride (6.50 g, 43.3 mmol) in ethanol (25 mL) was added 1,3-propanediamine (3.42 g, 46.0 mmol) dropwise over 5 min. The reaction was stirred over night at RT and the precipitated product was collected by filtration to yield 9.15 g of 3-(3-Amino-propylcarbamoyl)-pyrazine-2-carboxylic acid as a white solid (94%). This intermediate (200 mg) was dissolved in DMF (3 mL) and heated in a microwave reactor for 3 min at 175° C. to produce 7,8-Dihydro-6H-1,4,5,8a-tetraaza-fluoren-9-one, which was used without further purification.
後処理
- filtrationthe precipitated product was collected by filtration
出典と根拠
- ORDレコード
- ord-8d4a3241fc0942c78d192fdc27b1e7f9
- 出典データセット
- uspto-grants-2005_08
- 特許番号
- US06924284B2
関連ノート
読み込み中…