1-Chloro-N,N-2-trimethylpropenylamine → HCID 9921388、化合物

HRID 584252ノート

反応式

HRID 584252 の反応式
[Cl:1]C(N(C)C)=C(C)C.[CH3:9][N:10]1[CH:14]=[C:13]([NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:12]=[C:11]1[C:23]([OH:25])=O>>[CH3:9][N:10]1[CH:14]=[C:13]([NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:12]=[C:11]1[C:23]([Cl:1])=[O:25]

参加物

3

反応物 2

HCID 6407921-Chloro-N,N-2-trimethylpropenylamineHCID 27356364-[(tert-Butoxycarbonyl)amino]-1-methyl-1H-pyrrole-2-carboxylic acid

生成物 1

HCID 9921388HCID 9921388、化合物

実験手順

N-(1-chloro-2-methylprop-1-enyl)-N,N-dimethylamine (31 μL, 0.23 mmol) was added to a mixture of 1-methyl-4-(BOC amino)pyrrole-2-carboxylic acid (50 mg, 0.21 mmol) in CDCl3 (200 mL). After a few minutes, the 1H-NMR of the reaction mixture showed complete conversion of the acid to the acid chloride. The proton spectrum of this solution of acid chloride did not change on standing overnight at room temperature. 1H NMR (CDCl3): δ 7.35 (br s, 1H), 6.93 (d, J=2 Hz, 1H), 6.46 (br s, 1H), 3.82 (s, 3H), 1.50 (s, 9H).

後処理

  1. waitAfter a few minutes

出典と根拠

ORDレコード
ord-afa3c535208a450babc46ae57d263d2a
出典データセット
uspto-grants-2005_08
特許番号
US06924396B2

反応ノート

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