Phosgene → 5-Isocyanato-1,2,3-trimethoxybenzene

HRID 5846

反応式

HRID 5846 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11])[NH2:6].[C:14](Cl)(Cl)=[O:15]>C1(C)C=CC=CC=1>[CH3:13][O:12][C:8]1[CH:7]=[C:5]([N:6]=[C:14]=[O:15])[CH:4]=[C:3]([O:2][CH3:1])[C:9]=1[O:10][CH3:11]

参加物

4

反応物 2

HCID 6371PhosgeneHCID 322853,4,5-Trimethoxyaniline

生成物 1

HCID 5177665-Isocyanato-1,2,3-trimethoxybenzene

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 3,4,5-trimethoxyaniline (365 mg; 2.0 mmol) in toluene (20 ml) and phosgene (6 ml 20% in toluene; 12 mmol) was refluxed for 6 h. The solvent was removed under reduced pressure to give crude 3,4,5-trimethoxyphenylisocyanate. The crude product was added 3-[4-(4-chloro-phenyl)-1-piperazinyl]propanol (800 mg; 3.1 mmol) in toluene (25 ml) and refluxed for 16 h. The solvent was evaporated and the residue taken up in ethanol, which was treated with hydrogen chloride in ether. Recrystallization from ethanol/ether afforded 620 mg of the title compound M.p. 173.5°-174.5° C.

後処理

  1. temperaturewas refluxed for 6 h
  2. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-c66e87f2688c4345b675a14629eb0241
出典データセット
uspto-grants-1993_09
特許番号
US05246935

関連ノート

読み込み中…