Phosphorus oxychloride → 2-Chloro-6,7-difluoro-3-methylquinoxaline
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[NH:8][C:7](=O)[C:6]([CH3:14])=[N:5]2.O=P(Cl)(Cl)[Cl:17]>CN(C)C1C=CN=CC=1>[Cl:17][C:7]1[C:6]([CH3:14])=[N:5][C:4]2[C:9](=[CH:10][C:11]([F:12])=[C:2]([F:1])[CH:3]=2)[N:8]=1参加物
4
実験手順
6,7-Difluoro-3-methyl-1H-quinoxalin-2-one (2 g, prepared from 4,5-difluoro-1,2-phenylene-diamine and pyruvic acid according to general procedure (A), step 1) was mixed with POCl3 (20 ml) and 4-dimethylaminopyridine (10 mol %) and the mixture was refluxed for 2 hours. The mixture was allowed to cool and poured onto ice (300 ml), filtered and washed with water to afford the title compound.
後処理
- temperaturethe mixture was refluxed for 2 hours
- temperatureto cool
- additionpoured onto ice (300 ml)
- filtrationfiltered
- washwashed with water
出典と根拠
- ORDレコード
- ord-9e777484c7d441c3b6d1d48e99f1e23d
- 出典データセット
- uspto-grants-2005_08
- 特許番号
- US06927214B1
反応ノート
読み込み中…