2-Chloro-6-ethoxyquinoline-3-carbaldehyde → 2-Chloro-6-ethoxyquinoline-3-carbaldehyde-O-methyl-oxime

HRID 584665ノート

反応式

HRID 584665 の反応式
[Cl:1][C:2]1[C:11]([CH:12]=O)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:14][CH2:15][CH3:16])[CH:8]=2)[N:3]=1.Cl.[CH3:18][O:19][NH2:20].C(O)C>>[CH3:18][O:19][N:20]=[CH:12][C:11]1[C:2]([Cl:1])=[N:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([O:14][CH2:15][CH3:16])=[CH:6][CH:5]=2

参加物

3

反応物 2

HCID 7886582-Chloro-6-ethoxyquinoline-3-carbaldehydeHCID 22341071HCID 22341071、化合物

生成物 1

HCID 738840702-Chloro-6-ethoxyquinoline-3-carbaldehyde-O-methyl-oxime

実験手順

To a solution of 2-chloro-6-ethoxyquinoline-3-carbaldehyde (0.235 g, 1.0 mmol) in ethanol O-methylhydroxylamine hydrochloride (0.10 g, 1.1 mmol) was added. The reaction mixture was heated to reflux for 0.5 hours. After cooling to room temperature the precipitated compound was filtered and dried. Yield 180 mg. M.p. 142-4° C.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 0.5 hours
  3. filtrationwas filtered
  4. customdried

出典と根拠

ORDレコード
ord-a54f64eba8e247f0ae17a36478d376c7
出典データセット
uspto-grants-2005_08
特許番号
US06927214B1

反応ノート

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