Phosphorus tribromide → 2-Bromo-6,7-dichloro-3-trifluoromethylquinoxaline

HRID 584667ノート

反応式

HRID 584667 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[NH:8][C:7](=O)[C:6]([C:14]([F:17])([F:16])[F:15])=[N:5]2.P(Br)(Br)[Br:19]>>[Br:19][C:7]1[C:6]([C:14]([F:17])([F:16])[F:15])=[N:5][C:4]2[C:9](=[CH:10][C:11]([Cl:12])=[C:2]([Cl:1])[CH:3]=2)[N:8]=1

参加物

3

反応物 2

HCID 24614Phosphorus tribromideHCID 27678326,7-Dichloro-3-(trifluoromethyl)quinoxalin-2(1H)-one

生成物 1

HCID 223411132-Bromo-6,7-dichloro-3-trifluoromethylquinoxaline

反応条件

温度
140 °C

実験手順

6,7-Dichloro-3-trifluoromethyl-1H-quinoxalin-2-one (500 mg, 1.8 mmol) was dissolved in phosphorus tribromide (2.0 ml), and the solution was heated at 140° C. for 16 hours. The reaction mixture was cooled to room temperature, before it was poured out on ice (100 g) and extracted with dichloromethane. The organic phase was separated and dried with anhydrous sodium sulphate, then taken to dryness by rotary evaporation to leave a pale brown powder.

後処理

  1. temperatureThe reaction mixture was cooled to room temperature, before it
  2. additionwas poured out on ice (100 g)
  3. extractionextracted with dichloromethane
  4. customThe organic phase was separated
  5. dry with materialdried with anhydrous sodium sulphate
  6. customtaken to dryness by rotary evaporation
  7. customto leave a pale brown powder

出典と根拠

ORDレコード
ord-dc8899de52194adc91c5541aac4ae9ef
出典データセット
uspto-grants-2005_08
特許番号
US06927214B1

反応ノート

読み込み中…