Ethanol → HCID 178489023、化合物

HRID 584732ノート

反応式

HRID 584732 の反応式
[CH3:1][O:2][C:3]1[CH:23]=[CH:22][C:6]([C:7]([N:9]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[NH:10][C:11](=[S:13])[NH2:12])=O)=[CH:5][CH:4]=1.C(O)C>[OH-].[K+]>[CH3:21][O:20][C:17]1[CH:18]=[CH:19][C:14]([N:9]2[C:7]([C:6]3[CH:22]=[CH:23][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)=[N:12][C:11]([SH:13])=[N:10]2)=[CH:15][CH:16]=1

参加物

4

反応物 2

HCID 702EthanolHCID 223415752-(4-Methoxybenzoyl)-2-(4-methoxyphenyl)hydrazinecarbothioamide

生成物 1

HCID 178489023HCID 178489023、化合物収率 27.5%

試薬・触媒・溶媒 1

HCID 14797Potassium Hydroxide溶媒

実験手順

A mixture of 2-(4-methoxybenzoyl)-2-(4-methoxyphenyl)hydrazinecarbothioamide (200 mg, 0.604 mmol) in 10% potassium hydroxide solution (2 mL)-ethanol (1 mL) was refluxed for 4 hours. After cooling, the mixture was adjusted pH to ca. 2 and a generated precipitate was isolated by filtration, washed with water, and dried in vacuo to give 1,5-bis(4-methoxyphenyl)-1H-1,2,4-triazole-3-thiol (52 mg, 27.5% yield).

後処理

  1. temperaturewas refluxed for 4 hours
  2. temperatureAfter cooling
  3. customa generated precipitate was isolated by filtration
  4. washwashed with water
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-76a069c752c94499b24f64b5105348a3
出典データセット
uspto-grants-2005_08
特許番号
US06927230B2

反応ノート

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