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4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide → 2-Bromo-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide | HCID 127137 | — |
| 反応物 | 5-Amino-2-bromobenzoic acid | HCID 2769624 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-Bromo-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid | HCID 10456194 | 76.9% |
反応手順
According to the similar procedure in Synthesis Example 1, by using 5-amino-2-bromobenzoic acid (1.05 g, 6.12 mmole) which was prepared from Synthesis Example (4-1), DMF (50 ml) and 2,3,5,6-tetrafluoro-4-trifloromethylbenzyl bromide (1.16 g, 6.99 mmole), 2.02 g (76.9% yield) of 2-bromo-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid was obtained as a pale yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06927303B2 |
| 出典データセット | uspto-grants-2005_08 |
| ORD ID | ord-77a27deedfdb409e946759324330a536 |
| 出典メモ | uspto-grants-2005_08 |