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4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide → 2-Nitro-4-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide | HCID 127137 | — |
| 反応物 | 4-Amino-2-Nitrophenol | HCID 3417419 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-Nitro-4-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)phenol | HCID 10430075 | 40.1% |
反応手順
According to the similar procedure in Synthesis Example 1, by using 4-amino-2-nitrophenol (1.00 g, 6.49 mmole), DMF (30 ml), TEA (0.5 ml), and 2,3,5,6-tetrafluoro-4-trifluoromethylbenzyl bromide (1.30 g, 7.78 mmole), 1.00 g (40.0% yield) of 2-nitro-4-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)phenol was obtained as a reddish solid.:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06927303B2 |
| 出典データセット | uspto-grants-2005_08 |
| ORD ID | ord-56c55971ff944e42afbb4057312797f6 |
| 出典メモ | uspto-grants-2005_08 |