Hydrochloric Acid → HCID 22340319、化合物

HRID 585304ノート

反応式

HRID 585304 の反応式
[ClH:1].[Cl:2][CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH:14]C(=O)C)[CH:10]=2)[N:5]=1.Cl>>[ClH:2].[ClH:1].[Cl:2][CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH2:14])[CH:10]=2)[N:5]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 22340304HCID 22340304、化合物

生成物 1

HCID 22340319HCID 22340319、化合物収率 192.6%

反応条件

温度
100 °C

実験手順

To the N-[2-(chloromethyl)-6-quinolinyl]acetamide hydrochloride (900 mg, 3.32 mmol) obtained in Reference Example 6 was added 5N hydrochloric acid (17 ml), and the mixture was stirred at 100° C. for 2 hours. The reaction solution was concentrated under reduced pressure, and the resulting residue was washed with tetrahydrofuran to obtain the titled compound (849 mg) as powders.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. washthe resulting residue was washed with tetrahydrofuran

出典と根拠

ORDレコード
ord-7e9601225fc44cf2886c0c71f3a0d6c6
出典データセット
uspto-grants-2005_08
特許番号
US06930185B2

反応ノート

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