N-[2-(1-pyrrolidinylmethyl)-6-quinolinyl]acetamide → 2-(1-Pyrrolidinylmethyl)-6-quinolinylamine

HRID 585305ノート

反応式

HRID 585305 の反応式
[N:1]1([CH2:6][C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([NH:17]C(=O)C)[CH:13]=3)[N:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1>Cl>[N:1]1([CH2:6][C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([NH2:17])[CH:13]=3)[N:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

3

反応物 1

HCID 22340322N-[2-(1-pyrrolidinylmethyl)-6-quinolinyl]acetamide

生成物 1

HCID 119945322-(1-Pyrrolidinylmethyl)-6-quinolinylamine収率 97.9%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

反応条件

温度
110 °C

実験手順

To the N-[2-(1-pyrrolidinylmethyl)-6-quinolinyl]acetamide (5.53 g, 20.5 mmol) obtained in 1) of Example 7 was added concentrated hydrochloric acid (100 ml), the mixture was stirred at 110° C. for 1 hour, and the solvent was distilled off under reduced pressure. To the resulting residue was added ethyl acetate, the mixture was washed with an aqueous potassium carbonate solution and an aqueous saturated sodium chloride solution, dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain the titled compound (4.56 g) as a powder from ethyl acetate-hexane.

後処理

  1. distillationthe solvent was distilled off under reduced pressure
  2. additionTo the resulting residue was added ethyl acetate
  3. washthe mixture was washed with an aqueous potassium carbonate solution
  4. dry with materialan aqueous saturated sodium chloride solution, dried over anhydrous sodium sulfate
  5. distillationthe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-e9e2182d72664dcc9b3a40e108dcb3f6
出典データセット
uspto-grants-2005_08
特許番号
US06930185B2

反応ノート

読み込み中…