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Hydrochloric Acid → 4-(Cyclopropylcarbonyl)benzeneacetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | [4-(4-Chloro-1-oxobutyl)]-N-methoxy-N-methyl benzeneacetamide | HCID 9857023 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(Cyclopropylcarbonyl)benzeneacetic acid | HCID 193731 | 95% |
反応手順
Add purified [4-(4-chloro-1-oxobutyl)]-N-methoxy-N-methyl-benzeneacetamide (9.4 g, 330 mmol) to a solution of potassium hydroxide (22.0 g) in ethanol (160 mL). Stir 18 hours. Pour the solution into dilute hydrochloric acid (30 mL of concentrated hydrochloric acid in 500 mL of water). Extract the solution with three 500-mL portions of ethyl acetate. Dry the combined organic phases over anhydrous magnesium sulfate and concentrate to give the title compound (6.4 g, 95%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06930197B2 |
| 出典データセット | uspto-grants-2005_08 |
| ORD ID | ord-04aea1ae100e4c65be9c1c7b95b2904b |
| 出典メモ | uspto-grants-2005_08 |