1-(3-Methoxybenzoyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinol → Ethyl 5-[[1-[1-(3-methoxybenzoyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl]-1,2,3,4-tetrahydro-6-quinolinyl]oxy]pentanoate

HRID 585382

反応式

HRID 585382 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:20]=[CH:21][CH:22]=1)[C:6]([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11](O)[CH2:10][CH:9]1[CH3:19])=[O:7].[NH:23]1[C:32]2[C:27](=[CH:28][C:29]([O:33][CH2:34][CH2:35][CH2:36][CH2:37][C:38]([O:40][CH2:41][CH3:42])=[O:39])=[CH:30][CH:31]=2)[CH2:26][CH2:25][CH2:24]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:20]=[CH:21][CH:22]=1)[C:6]([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]([N:23]2[C:32]3[C:27](=[CH:28][C:29]([O:33][CH2:34][CH2:35][CH2:36][CH2:37][C:38]([O:40][CH2:41][CH3:42])=[O:39])=[CH:30][CH:31]=3)[CH2:26][CH2:25][CH2:24]2)[CH2:10][CH:9]1[CH3:19])=[O:7]

参加物

3

反応物 2

HCID 223392321-(3-Methoxybenzoyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinolHCID 22339349Ethyl 5-[(1,2,3,4-tetrahydro-6-quinolinyl)oxy]pentanoate

生成物 1

HCID 22339202Ethyl 5-[[1-[1-(3-methoxybenzoyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl]-1,2,3,4-tetrahydro-6-quinolinyl]oxy]pentanoate収率 26%

実験手順

Starting with 1-(3-methoxybenzoyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinol (1.0 g, 3.36 mmol) prepared in Reference Example 21 and ethyl 5-[(1,2,3,4-tetrahydro-6-quinolinyl)oxy]pentanoate (2.14 g, 7.73 mmol), the same procedure as shown in Example 1 was repeated to give the titled compound (479 mg, yield: 26%) as a colorless oil. (cis:trans=1:3.5)

出典と根拠

ORDレコード
ord-89336add9766415583dae3d8c90294d3
出典データセット
uspto-grants-2005_08
特許番号
US06930104B2

関連ノート

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