1-(3,4,5-Trimethoxybenzoyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinol → Ethyl 5-[[1-[2-methyl-1-(3,4,5-trimethoxybenzoyl)-1,2,3,4-tetrahydro-4-quinolinyl]-1,2,3,4-tetrahydro-6-quinolinyl]oxy]pentanoate

HRID 585383

反応式

HRID 585383 の反応式
[CH3:1][CH:2]1[CH2:11][CH:10](O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[C:13](=[O:26])[C:14]1[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22][CH3:23])=[C:16]([O:24][CH3:25])[CH:15]=1.[NH:27]1[C:36]2[C:31](=[CH:32][C:33]([O:37][CH2:38][CH2:39][CH2:40][CH2:41][C:42]([O:44][CH2:45][CH3:46])=[O:43])=[CH:34][CH:35]=2)[CH2:30][CH2:29][CH2:28]1>>[CH3:1][CH:2]1[CH2:11][CH:10]([N:27]2[C:36]3[C:31](=[CH:32][C:33]([O:37][CH2:38][CH2:39][CH2:40][CH2:41][C:42]([O:44][CH2:45][CH3:46])=[O:43])=[CH:34][CH:35]=3)[CH2:30][CH2:29][CH2:28]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[C:13](=[O:26])[C:14]1[CH:15]=[C:16]([O:24][CH3:25])[C:17]([O:22][CH3:23])=[C:18]([O:20][CH3:21])[CH:19]=1

参加物

3

反応物 2

HCID 223392301-(3,4,5-Trimethoxybenzoyl)-2-methyl-1,2,3,4-tetrahydro-4-quinolinolHCID 22339349Ethyl 5-[(1,2,3,4-tetrahydro-6-quinolinyl)oxy]pentanoate

生成物 1

HCID 22339267Ethyl 5-[[1-[2-methyl-1-(3,4,5-trimethoxybenzoyl)-1,2,3,4-tetrahydro-4-quinolinyl]-1,2,3,4-tetrahydro-6-quinolinyl]oxy]pentanoate収率 40%

実験手順

Starting with 2-methyl-1-(3,4,5-trimethoxybenzoyl)-1,2,3,4-tetrahydro-4-quinolinol (1.3 g, 3.6 mmol) prepared in Reference Example 22 and ethyl 5-[(1,2,3,4-tetrahydro-6-quinolinyl)oxy]pentanoate (2.30 g, 8.28 mmol), the same procedure as shown in Example 1 was repeated to give the titled compound (806 mg, yield: 40%) as a colorless oil. (cis:trans=1:1.3)

出典と根拠

ORDレコード
ord-bb0e467e4ba740f8a9332e07f5d9e10a
出典データセット
uspto-grants-2005_08
特許番号
US06930104B2

関連ノート

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