Cyclohexylamine → 1-Cyclohexyl-2-oxopyrrolidine-3-carboxylic acid
反応式
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CC1(C)[O:16][C:15](=O)[C:12]2([CH2:14][CH2:13]2)[C:11](=[O:18])[O:10]1>C(O)C>[CH:1]1([N:7]2[CH2:14][CH2:13][CH:12]([C:11]([OH:18])=[O:10])[C:15]2=[O:16])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
4
実験手順
A mixture of cyclohexylamine (1.02 mL; 8.82 mmol) and 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.5 g; 2.94 mmol) in ethanol (3 mL) was irradiated in a microwave oven for 3 minutes at 100° C. and concentrated under reduced pressure. The crude material was purified by flash chromatography on silica gel (eluent 30 to 100% ethyl acetate in heptane with 5% acetic acid) to afford 0.228 g (36%) of 1-cyclohexyl-2-oxopyrrolidine-3-carboxylic acid.
後処理
- customwas irradiated in a microwave oven for 3 minutes at 100° C.
- concentrationconcentrated under reduced pressure
- customThe crude material was purified by flash chromatography on silica gel (eluent 30 to 100% ethyl acetate in heptane with 5% acetic acid)
出典と根拠
- ORDレコード
- ord-ff334f9e31ef4c6dbfa93fb66370d353
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434722B2
反応ノート
読み込み中…