Hexanenitrile, 5-oxo- → HCID 21927832、化合物
反応式
O=[C:2]([CH3:8])[CH2:3][CH2:4][CH2:5][C:6]#[N:7].[NH2:9][C:10]1[C:15]([CH:16]=O)=[CH:14][CH:13]=[CH:12][N:11]=1>C(O)C>[CH3:8][C:2]1[C:3]([CH2:4][CH2:5][C:6]#[N:7])=[CH:16][C:15]2[C:10](=[N:11][CH:12]=[CH:13][CH:14]=2)[N:9]=1参加物
4
実験手順
A mixture of 5-oxo-hexanenitrile (5 mL, TCI-US), 2-amino-3-formylpyridine (7 g, J. Org. Chem. 1983, vol.48, p3401) and ethanol (100 mL) was heated to reflux for 12 hours. Following evaporation of the solvent, the residue was chromatographed (silica gel, ethyl acetate) to give 4-[1,8]naphthyridin-2-yl-butyronitirile and the title product as colorless solids. 1H (CDCl3) δ 2.29 (3H, s); 2.83 (2H, t); 3.18 (2H, t); 7.48 (1H, dd); 8.04 (1H, s); 8.20 (1H, dd); 9.03 (1H, dd). Step 2
後処理
- temperaturewas heated
- temperatureto reflux for 12 hours
- customevaporation of the solvent
- customthe residue was chromatographed (silica gel, ethyl acetate)
- customto give 4-[1,8]naphthyridin-2-yl-butyronitirile
出典と根拠
- ORDレコード
- ord-760887f24401417490bba0073d70e238
- 出典データセット
- uspto-grants-2005_08
- 特許番号
- US06933304B2
反応ノート
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