HCID 332828、化合物 → 4-(1,3-Dioxaindan-5-yl)oxane-2,6-dione
反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]([CH2:15][C:16]([OH:18])=[O:17])[CH2:11][C:12]([OH:14])=O)=[CH:9][C:4]=2[O:3][CH2:2]1>C(OC(=O)C)(=O)C>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]3[CH2:11][C:12](=[O:14])[O:18][C:16](=[O:17])[CH2:15]3)=[CH:9][C:4]=2[O:3][CH2:2]1参加物
3
実験手順
3-(1,3-benzodioxol-5-yl)pentanedioic acid (2 g, 7.9 mmoles) was suspended in acetic anhydride (50 ml) and refluxed for two hours. The reaction mixture was allowed to cool to room temperature and the solvent was removed under reduced pressure. The residue was triturated with ether to give the product (1.3 g, 70%). 1H NMR (DMSO-d6) δ 6.91 (m, 1H), 6.89 (m, 1H), 6.72 (m, 1H), 6.01 (s, 2H), 3.53-3.41 (m, 1H), 3.07-2.89 (m, 4H).
後処理
- temperaturerefluxed for two hours
- customthe solvent was removed under reduced pressure
- customThe residue was triturated with ether
出典と根拠
- ORDレコード
- ord-923881117c3d4bc58d47c6875caa6a24
- 出典データセット
- uspto-grants-2005_08
- 特許番号
- US06933304B2
反応ノート
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