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6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione → 2-Oxo-1-(4-(trifluoromethoxy)phenyl)pyrrolidine-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione | HCID 79720 | — |
| 反応物 | 4-(Trifluoromethoxy)aniline | HCID 600848 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Oxo-1-(4-(trifluoromethoxy)phenyl)pyrrolidine-3-carboxylic acid | HCID 24689361 | 82.3% |
反応手順
This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g, 1.47 mmol) and 4-(trifluoromethoxy)aniline (0.595 mL; 4.41 mmol) in ethanol (3 mL). 2-oxo-1-(4-(trifluoromethoxy)phenyl)pyrrolidine-3-carboxylic acid 0.350 g (82%) was obtained as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434722B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-56b333c44e0549008827d4b10428caf3 |
| 出典メモ | uspto-grants-2016_09 |