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2,6-Difluoroaniline → 1-(2,6-Difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,6-Difluoroaniline | HCID 79647 | — |
| 反応物 | 6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione | HCID 79720 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-(2,6-Difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid | HCID 24275252 | 46% |
反応手順
This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g; 1.45 mmol) and 2,6-difluoroaniline (0.575 g; 4.36 mmol) in ethanol (3 mL). 1-(2,6-difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid 0.161 g (46%) was obtained as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434722B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-403f6f210d654a6da0ce8deb6b58b2e6 |
| 出典メモ | uspto-grants-2016_09 |