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3,4-Dimethylaniline → 1-(3,4-Dimethylphenyl)-2-oxopyrrolidine-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,4-Dimethylaniline | HCID 7248 | — |
| 反応物 | 6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione | HCID 79720 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-(3,4-Dimethylphenyl)-2-oxopyrrolidine-3-carboxylic acid | HCID 24275212 | 86.3% |
反応手順
This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g; 1.45 mmol) and 3,4-dimethylaniline (0.540 g; 4.36 mmol) in ethanol (3 mL). 1-(3,4-dimethylphenyl)-2-oxopyrrolidine-3-carboxylic acid 0.292 g (86%) was obtained as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434722B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-262dbf38dde742b0b51facbf862dca32 |
| 出典メモ | uspto-grants-2016_09 |