Phosgene → 3-Chloro-5-isocyanatoisoquinoline

HRID 585996

反応式

HRID 585996 の反応式
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[C:5]([Cl:12])[N:6]=[CH:7]2.[C:13](Cl)(Cl)=[O:14]>C1(C)C=CC=CC=1.C(N(CC)CC)C>[Cl:12][C:5]1[N:6]=[CH:7][C:8]2[C:3]([CH:4]=1)=[C:2]([N:1]=[C:13]=[O:14])[CH:11]=[CH:10][CH:9]=2

参加物

5

反応物 2

HCID 6371PhosgeneHCID 167490403-Chloroisoquinolin-5-amine

生成物 1

HCID 223376853-Chloro-5-isocyanatoisoquinoline

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒2 回HCID 8471Triethylamine溶媒

実験手順

5-Amino-3-chloroisoquinoline (740 mg, 4.15 mmol) was suspended in toluene (20 mL) and treated with 20% w/v phosgene solution in toluene (9 mL) and triethylamine (5 mL). The mixture was refluxed overnight and was then concentrated in vacuo and used in the next step without further purification.

後処理

  1. temperatureThe mixture was refluxed overnight
  2. concentrationwas then concentrated in vacuo
  3. customused in the next step without further purification

出典と根拠

ORDレコード
ord-757cd4c7dec242c181a7146cfc9b9d54
出典データセット
uspto-grants-2005_08
特許番号
US06933311B2

関連ノート

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