Methyl 2-{[(benzyloxy)carbonyl]amino}-2-(dimethyl phosphono)acetate → 2-Benzyloxycarbonylamino-5,5,6-trimethyl-heptanoic acid

反応式

[CH3:1][C:2]([CH3:9])([CH:6]([CH3:8])[CH3:7])[CH2:3][CH:4]=O.C[O:11][C:12]([CH:14](P(OC)(OC)=O)[NH:15][C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17])=[O:13]>>[CH2:19]([O:18][C:16]([NH:15][CH:14]([CH2:4][CH2:3][C:2]([CH3:9])([CH3:1])[CH:6]([CH3:8])[CH3:7])[C:12]([OH:13])=[O:11])=[O:17])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

参加物

反応物 2

HCID 2734718Methyl 2-{[(benzyloxy)carbonyl]amino}-2-(dimethyl phosphono)acetate

HCID 124253353,3,4-Trimethylpentanal

生成物 1

HCID 223294082-Benzyloxycarbonylamino-5,5,6-trimethyl-heptanoic acid

実験手順

This aldehyde may be converted to the title compound by reaction with N-(Benzyloxycarbonyl)-α-phosphonoglycine trimethyl ester, followed by catalytic reduction and hydrolysis by the procedures described in Example 4.

出典と根拠

ORDレコード: ord-03ff5798901e4c71990024c28b3550d5
出典データセット: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06936606B2

反応ノート

読み込み中…