Hydrochloric Acid → 5-(3-Bromophenyl)-1H-1,2,4-triazole

HRID 586314

反応式

HRID 586314 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12](COCC[Si](C)(C)C)[N:11]=[CH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.Cl>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:12][N:11]=[CH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 22329519HCID 22329519、化合物

生成物 1

HCID 124615465-(3-Bromophenyl)-1H-1,2,4-triazole収率 89.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

This reaction was carried out as described in Example 40, step b, using 5-(3-bromophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-[1,2,4]triazole (2.88 g, 8.1 mmol), 2 N HCl (50 ml) and ethanol (50 ml) to yield the title compound (1.62 g, 89%): 1H NMR (360 MHz, DMSO-d6) δ 8.70 (1H, s), 8.16 (1H, s), 8.01 (1H, d, J 7.8 Hz), 7.63 (1H, d, J 7.8 Hz), 7.46 (1H, t, J 7.8 Hz).

出典と根拠

ORDレコード
ord-ed683daacb8b4ec984001d9b2ef31b96
出典データセット
uspto-grants-2005_08
特許番号
US06936608B2

関連ノート

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