Hydrochloric Acid → 1-[2-(4-Pyridinyl)ethyl]piperazine hydrochloride
反応式
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.C(OCC)(=O)C.[ClH:28]>C(OCC)C>[ClH:28].[N:19]1[CH:20]=[CH:21][C:16]([CH2:15][CH2:14][N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[CH:17][CH:18]=1参加物
5
実験手順
Alternatively, 1-Boc-4-[2-(4-pyridinyl)ethyl]piperazine (1.0 g, 3.43 mmol) was dissolved in ethyl ether. Ethyl acetate (15 mL) saturated with HCl was added, and the mixture stirred for 30 min at room temperature. The mixture was concentrated under vacuum and provided 1-[2-(4-pyridinyl)ethyl]piperazine hydrochloride (900 mg, 87%) as a tan solid.
後処理
- concentrationThe mixture was concentrated under vacuum
出典と根拠
- ORDレコード
- ord-4a764d57ec994a45a57514c453bdd9f7
- 出典データセット
- uspto-grants-2005_08
- 特許番号
- US06936611B2
反応ノート
読み込み中…