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5-Chloro-2-methylphenyl isothiocyanate → 1-(5-Chloro-2-methyl-phenyl)-3-(4-methyl-oxazol-2-yl)-thiourea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Chloro-2-methylphenyl isothiocyanate | HCID 29519 | — |
| 反応物 | 4-Methyloxazol-2-amine | HCID 535824 | — |
| 生成物 | 1-(5-Chloro-2-methyl-phenyl)-3-(4-methyl-oxazol-2-yl)-thiourea | HCID 9921815 | 54.1% |
反応手順
Prepared using Method A from 10.0 g (54.5 mmol) of 5-chloro-2-methyl-phenyl isothiocyanate and 5.39 g (55 mmol) of 4-methyl-2-amino-oxazole to give 8.3 g of title compound as a yellow solid, m.p. 207-208° C. An additional crop (4.8 g, m.p. 207-208° C.) was obtained from the mother liquor (86% combined yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06936630B2 |
| 出典データセット | uspto-grants-2005_08 |
| ORD ID | ord-44e731206ffe4858bf931064cf3976e5 |
| 出典メモ | uspto-grants-2005_08 |