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3-Chloro-6-isothiocyanatotoluene → 1-(4-Chloro-2-methyl-phenyl)-3-(4-methyl-oxazol-2-yl)-thiourea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Chloro-6-isothiocyanatotoluene | HCID 90021 | — |
| 反応物 | 4-Methyloxazol-2-amine | HCID 535824 | — |
| 反応物 | Dichloromethane methanol | HCID 21226129 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 1-(4-Chloro-2-methyl-phenyl)-3-(4-methyl-oxazol-2-yl)-thiourea | HCID 9921816 | — |
反応手順
Prepared using Method A from 4.04 g (22 mmol) of 4-chloro-2-methyl-phenyl isothiocyanate and 2.16 g (22 mmol) of 2-amino-4-methyloxazole to give 4.5 g of crude title compound. Pure title compound was obtained by flash chromatography (silica Merck 60, CH2Cl2—CH3OH, 19:1) and crystallization from CH3CN to give 2.12 g of the title compound as a yellow solid (72.5% yield, m.p. 214° C. with decomposition).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06936630B2 |
| 出典データセット | uspto-grants-2005_08 |
| ORD ID | ord-c70b46d569054d3fb0d1ed8f7d81116e |
| 出典メモ | uspto-grants-2005_08 |